Hoy a la mañana me enviaron esto del laburo (trabajo de seguridad) después llamé por que no me pienso poner ninguna y me dijeron que probablemente puedo llegar a perder el puesto de trabajo (tengo casi 5 años de antigüedad en la empresa). Por qué nadie dice algo contra esto?

2021.12.09 01:11 baNeTR23 Hoy a la mañana me enviaron esto del laburo (trabajo de seguridad) después llamé por que no me pienso poner ninguna y me dijeron que probablemente puedo llegar a perder el puesto de trabajo (tengo casi 5 años de antigüedad en la empresa). Por qué nadie dice algo contra esto?

Hoy a la mañana me enviaron esto del laburo (trabajo de seguridad) después llamé por que no me pienso poner ninguna y me dijeron que probablemente puedo llegar a perder el puesto de trabajo (tengo casi 5 años de antigüedad en la empresa). Por qué nadie dice algo contra esto? submitted by baNeTR23 to argentina [link] [comments]


2021.12.09 01:11 millman1313 Just put in my truck 2015 Chevy. It basically stopped the truck from going back and forth from V8-V4. Stays in V8 now and man can I tell a difference. I’ve also noticed my transmission not action up as well. Anyone else??

Just put in my truck 2015 Chevy. It basically stopped the truck from going back and forth from V8-V4. Stays in V8 now and man can I tell a difference. I’ve also noticed my transmission not action up as well. Anyone else?? submitted by millman1313 to ChevyTrucks [link] [comments]


2021.12.09 01:11 ClassicGuy2010 If the German Empire won WW1?

submitted by ClassicGuy2010 to HistoryWhatIf [link] [comments]


2021.12.09 01:11 Waste-Many5991 The Best After-Christmas Sales of 2021. Buy Microsoft Office 2010 Professional Plus 32/64 Bit.[ On discount -65%] Only Price £34.99

The Best After-Christmas Sales of 2021. Buy Microsoft Office 2010 Professional Plus 32/64 Bit.[ On discount -65%] Only Price £34.99 submitted by Waste-Many5991 to microsoftoffice [link] [comments]


2021.12.09 01:11 Dr_Brombo There's a special place in hell for hackers that commit bank fraud

To the asshole hacker that stole money from me and my wife tonight: If I ever find you, I will burn your house down with you tied up inside of it.
submitted by Dr_Brombo to venting [link] [comments]


2021.12.09 01:11 sburgess86 The structural basis of mRNA recognition and binding by eukaryotic pseudouridine synthase PUS1

submitted by sburgess86 to BiologyPreprints [link] [comments]


2021.12.09 01:11 ZengaStromboli Could this footage potentially cause seizures?

https://youtu.be/-KGQ4PfQdTc
I wanted to show it off because it's cool as shit, but parts of it give me pause. What do you think?
submitted by ZengaStromboli to NoStupidQuestions [link] [comments]


2021.12.09 01:11 thewirdz NO COPYRIGHT MUSIC // Poolside - LiQWYD [Audio Library Release]

NO COPYRIGHT MUSIC // Poolside - LiQWYD [Audio Library Release] submitted by thewirdz to PopularOnYouTube [link] [comments]


2021.12.09 01:11 BobFredricson2 Ultimate Amongasaur

Ultimate Amongasaur submitted by BobFredricson2 to Ben10 [link] [comments]


2021.12.09 01:11 Randum__ Call of Duty: Warzone - Rebirth Island Quads Win Gameplay - Ak47 (CW) / Mac10 - [PC] - No Commentary

Call of Duty: Warzone - Rebirth Island Quads Win Gameplay - Ak47 (CW) / Mac10 - [PC] - No Commentary submitted by Randum__ to Warzone [link] [comments]


2021.12.09 01:11 hiepatitis1 This quality control is so bad

This quality control is so bad submitted by hiepatitis1 to basketballcards [link] [comments]


2021.12.09 01:11 Half-DrunkPhilosophy Would like to ask a legit question about how a CERTAIN dungeon mechanic works

But you know, even having the WORD in a post seems to make the modbots go crazy, so, could a veteran player DM me so I can find out this, likely simple THING of a certain sort of, effect of the visual sort which applies to one's chosen character vis a vis their appeal? THANKs and such.
submitted by Half-DrunkPhilosophy to elderscrollsonline [link] [comments]


2021.12.09 01:11 sburgess86 Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists submitted by sburgess86 to BiologyPreprints [link] [comments]


2021.12.09 01:11 ayuswan [FOR HIRE] Hello! I'm doing half body drawings for $15 and full body for $30! Wow, FFXIV, DnD and more! :) I can finish before Xmas! Portfolio in the comments!

submitted by ayuswan to Artistsforhire [link] [comments]


2021.12.09 01:11 No_Limit5915 Is SRNE Part of this as well? They do work with Texas A&M already.

COVID-19 Breakthrough: Scientists Discover How the SARS-CoV-2 Virus Evades Our Immune System
TOPICS:COVID-19ImmunologyInfectious DiseasesTexas A&M University
By Gracie Blackwell, Texas A&M College of Medicine December 8, 2021
📷
The expression of the immune response gene ??NLRC5 (red purple) is suppressed in SARS-CoV-2 (green) infected cells. Credit: Koichi Kobayashi
A discovery by researchers at the Texas A&M College of Medicine could lead to new therapies to prevent the virus from proliferating in the human body.
The immune system is a complex network of cells and proteins that is designed to fight off infection and disease, especially those like the coronavirus, or SARS-CoV-2, that can cause numerous issues in the human body. But many individuals are still at risk of being infected with the coronavirus, letting it replicate in the body and further transmitting to other individuals.
The underlying mechanism of how SARS-CoV-2 escapes from the immune system has been poorly understood. However, researchers from the Texas A&M University College of Medicine and Hokkaido University have recently discovered a major mechanism that explains how SARS-CoV-2 can escape from the immune system and replicate in the human body. Their findings were recently published in the journal Nature Communications.
📷
SARS-CoV-2 escapes from immune responses by cytotoxic T cells via impaired MHC-I expression which is caused by reducing both the amount and function of NLRC5. Credit: Koichi Kobayashi
“We found that the SARS-CoV-2 virus carries a suppressive gene that acts to inhibit a human gene in the immune system that is essential for destroying infected cells,” said Dr. Koichi Kobayashi, adjunct professor at the College of Medicine and lead author of the paper.
Naturally, the cells in a human’s immune system are able to control virus infection by destroying infected cells so that the virus cannot be replicated. The gene that is essential in executing this process, called NLRC5, regulates major histocompatibility complex (MHC) class I genes, which are genes that create a pathway that is vital in providing antiviral immunity. Kobayashi and his colleagues discovered this in 2012.
“During infection, the amount and activity of NLRC5 gene become augmented in order to boost our ability of eradication of viruses,” Kobayashi said. “We discovered that the reason why SARS-CoV-2 can replicate so easily is because the virus carries a suppressive gene, called ORF6, that acts to inhibit the function of NLRC5, thus inhibiting the MHC class I pathway as well.”
📷
Dr. Koichi Kobayashi, adjunct professor at the College of Medicine and lead author of the paper. Credit: Texas A&M College of Medicine
Kobayashi, who holds a joint appointment as a professor at Hokkaido University in Japan, collaborated with Paul de Figueiredo, associate professor in the Department of Microbial Pathogenesis and Immunology at the College of Medicine, on this paper.
Kobayashi and his team’s discovery shed light on the mechanism to how SARS-CoV-2 can replicate in the human body and can potentially lead to the development of new therapeutics to prevent the coronavirus from escaping the immune system and replicating in the body.
Although the introduction of COVID-19 vaccines, such as the Pfizer and Moderna vaccines, can lower an individual’s chance of contracting the virus, there is currently no permanent therapy that can entirely prevent a human from contracting SARS-CoV-2.
“We hope that this new discovery will allow us to develop a new drug that can block this gene so our immune system will be able to fight off the coronavirus for good,” de Figueiredo said.
Reference: “SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis” by Ji-Seung Yoo, Michihito Sasaki, Steven X. Cho, Yusuke Kasuga, Baohui Zhu, Ryota Ouda, Yasuko Orba, Paul de Figueiredo, Hirofumi Sawa and Koichi S. Kobayashi, 15 November 2021, Nature Communications.
https://scitechdaily.com/covid-19-breakthrough-scientists-discover-how-the-sars-cov-2-virus-evades-our-immune-system/
submitted by No_Limit5915 to BANDOFBROTHERSOFSRNE [link] [comments]


2021.12.09 01:11 Diligent_Flamingo_33 Schools Are Closing Classrooms on Fridays. Parents Are Furious.

https://news.yahoo.com/schools-closing-classrooms-fridays-parents-124812995.html
I totally get it. I'm burned out. Many of the other teachers at my school are burned out. Many students are unmotivated. We're still very much in the pandemic and it's not easy.
One amusing line from the article: "Kisselman, who is working out of her living room as a county case manager, said it was 'nearly impossible' for her to help Sophia, who has attention deficit hyperactivity disorder, with her schoolwork." Um, yeah. Imagine how it is for teachers when we have at least 5-10 students with different learning abilities, plus the rest of our class. I truly believe less people would have kids if they couldn't send their kids to school during the day.
submitted by Diligent_Flamingo_33 to Teachers [link] [comments]


2021.12.09 01:11 hyrollah Coming To 1st Kraken Game!

My family and I will be coming to our first Kraken game on the 18th. Can you guys tell me if there’s any ‘decent’ hotels within walking distance from the arena?
submitted by hyrollah to SeattleKraken [link] [comments]


2021.12.09 01:11 kittyblanket "I'm the best present."

submitted by kittyblanket to aww [link] [comments]


2021.12.09 01:11 MayorZane I drew pixel art of one of my favorite Megaman Legends boss, the Balkon Gerät!

submitted by MayorZane to MegaManLegends [link] [comments]


2021.12.09 01:11 BasicDave817 Amanda Pappas WINK news

Amanda Pappas WINK news submitted by BasicDave817 to hot_reporters [link] [comments]


2021.12.09 01:11 Sad-Wasabi-3634 Has anyone thought of curious shellfolk with concurrent timelines?

In theory you could play down a one mana follower and then get infinite 1-cost followers for free in hand since shellfolk copies it to hand and reduces the cost. Just a thought I had.
submitted by Sad-Wasabi-3634 to LegendsOfRuneterra [link] [comments]


2021.12.09 01:11 North-Technician8734 Death God

Death God submitted by North-Technician8734 to WomboArt [link] [comments]


2021.12.09 01:11 Honey-Scooters I feel so intensely and I'm tired

It feels like something is tugging my heart down, clouding my thoughts, and obstructing my vision. I just feel so fucking hopeless. I feel so drained and yet emotionally intense and feeling everything so strongly.
I've been sh free for 25 days now, but I still get the thoughts, "You/ I should cut youmyself," and "You/ I should kill youmyself". I've been better about cutting off the thought right at, "You/ I should," but this time when I stopped it, it didn't really work. I didn't say it in my head, but I spiraled about it.
Why do I always think this? Why can't I just fucking stop? I'm not even thinking it, it just comes into my head- why? It's so fucked up. I'm trying to get better and yet this shit keeps happening. What the fuck? What the fuck is wrong with me?
I just let myself think about cutting for a minute again. Ugh. I don't know why. I'm just tired man. It hurts. My heart hurts and I don't have a whole lot of energy to deal with it. I'm emotionally and physically exhausted and yet I'm still feeling so intensely. I just want to sh again. It would be so much easier. Maybe I could work on my Psych essay I've been meaning to do or work on the oil painting I've been putting off if I cut. Fuck. I just want to feel better.
submitted by Honey-Scooters to mentalhealth [link] [comments]


2021.12.09 01:11 sburgess86 Insights on the mutational landscape of the SARS-CoV-2 Omicron variant

submitted by sburgess86 to BiologyPreprints [link] [comments]


2021.12.09 01:11 MrKree "Halo Infinite will not launch with Co-op play" Meanwhile when you End Game in Campaign

submitted by MrKree to halo [link] [comments]


http://aekoptev.ru